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S0447

SIS3

Name: SIS3
Brand: SIGMA

≥98% (HPLC), TGF-β1/ALK-5 phosphorylation inhibitor, powder

Synonym(s):

(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₇N₃O₃ · HCl

CAS Number:

521984-48-5

Molecular Weight:

489.99

UNSPSC Code:

12352200

PubChem Substance ID:

24724599

NACRES:

NA.77

MDL number:

MFCD09265258

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

SIS3, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

H₂O: <2 mg/mL, DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35

InChI

1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;

InChI key

CDKIEBFIMCSCBB-CALJPSDSSA-N

Description

Application

Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.

Biochem/physiol Actions

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.

SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
S0447-5MG	04061836830274