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S1688

SR 57227A

solid

Synonym(s):

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H14ClN3 · HCl
CAS Number:
77145-61-0
Molecular Weight:
248.15
NACRES:
NA.77
PubChem Substance ID:
24278109
UNSPSC Code:
12352200
MDL number:
MFCD01756430
Form:
solid
Quality level:
100
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form

solid

Quality Level

100

color

white

solubility

H2O: soluble 9 mg/mL

SMILES string

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

InChI key

FUMINTAAUJUVMP-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Application

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Biochem/physiol Actions

Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

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