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S3442

SB 216763

Name: SB 216763
Brand: SIGMA

>98% (HPLC), glycogen synthase kinase-3 inhibitor

Synonym(s):

3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₂N₂O₂Cl₂

CAS Number:

280744-09-4

Molecular Weight:

371.22

UNSPSC Code:

12352200

PubChem Substance ID:

24278616

NACRES:

NA.77

MDL number:

MFCD09753369

Assay:

>98% (HPLC)

Quality level:

100

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Properties

Product Name

SB 216763, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

color

orange

solubility

DMSO: soluble 20 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

−20°C

SMILES string

Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14

InChI

1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

InChI key

JCSGFHVFHSKIJH-UHFFFAOYSA-N

Gene Information

human ... GSK3A(2931), GSK3B(2932)

Description

Application

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Biochem/physiol Actions

Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology