S4826
SMIFH2
≥98% (HPLC), actin assembly inhibitor, powder
Synonym(s):
1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
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About This Item
Empirical Formula (Hill Notation):
C15H9BrN2O3S
CAS Number:
Molecular Weight:
377.21
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
SMIFH2, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
light yellow to yellow-green
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
S=C1N(C(=O)\C(=C\c3[o]ccc3)\C(=O)N1)c2cc(ccc2)Br
InChI
1S/C15H9BrN2O3S/c16-9-3-1-4-10(7-9)18-14(20)12(13(19)17-15(18)22)8-11-5-2-6-21-11/h1-8H,(H,17,19,22)/b12-8+
InChI key
MVFJHEQDISFYIS-XYOKQWHBSA-N
Application
SMIFH2 was used to decipher the role of mDia2 in controlling microtubule dynamics and myofibroblast differentiation.1
Biochem/physiol Actions
SMIFH2 is an inhibitor of formin homology 2 domains. The compound is a first small molecule inhibitor of formin-mediated actin assembly that disrupts formin dependent processes from yeast to mammals. SMIFH2 may be a useful drug for identifying cellular processes dependent on formin-mediated actin assembly in a broad range of experimental systems. Formin is an actin nucleation factor.
SMIFH2 is an inhibitor of formin-mediated actin assembly that disrupts formin dependent processes.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S4826-25MG | 04061833221334 |
| S4826-5MG | 04061836932169 |