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S8251

Succinylcholine chloride dihydrate

98.0-102.0%, Cholinergic antagonist, solid

Synonym(s):

Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride

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About This Item

Linear Formula:
[(CH3)3NCH2CH2OCOCH2]2Cl2 · 2H2O
CAS Number:
6101-15-1
Molecular Weight:
397.34
NACRES:
NA.77
PubChem Substance ID:
24277873
UNSPSC Code:
41116107
EC Number:
200-747-4
MDL number:
MFCD00150564
Beilstein/REAXYS Number:
3922827
Assay:
98.0-102.0%
Form:
solid
Quality level:
100
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Product Name

Succinylcholine chloride dihydrate, 98.0-102.0%, solid

Quality Level

100

assay

98.0-102.0%

form

solid

color

white

solubility

H2O: complete 100 mg/ml, clear to slightly hazy, colorless, H2O: soluble (unstable at pH > 9.)

originator

Novartis

SMILES string

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

InChI key

FFSBEIRFVXGRPR-UHFFFAOYSA-L

Application

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.4,5

Biochem/physiol Actions

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.
Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.3

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP8101
MKCH8005
MKCC3936
MKBZ5191V
MKBW5278V

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William R Reed et al.
Experimental brain research, 225(2), 205-215 (2012-12-12)
Increasing our knowledge regarding intrafusal fiber distribution and physiology of paraspinal proprioceptors may provide key insights regarding proprioceptive deficits in trunk control associated with low back pain and lead to more effective clinical intervention. The use of vertebral movement as
Claus Bretlau et al.
Anesthesia and analgesia, 116(3), 596-601 (2013-02-13)
Succinylcholine is usually metabolized quickly by the butyrylcholinesterase enzyme (BChE) but genetic variants of BChE may prolong the duration of action. The Kalow (K) variant is the most common mutation in the butyrylcholinesterase gene (BCHE), being present in 25% of
J A Jeevendra Martyn et al.
Anesthesiology, 104(1), 158-169 (2006-01-06)
Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain
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Global Trade Item Number

SKUGTIN
S8251-25G04061836960612