S8688
SR 59230A
≥98% (HPLC), powder, β3-Adrenoceptor antagonist
Synonym(s):
3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
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About This Item
Empirical Formula (Hill Notation):
C21H27NO2 · C2H2O4
CAS Number:
Molecular Weight:
415.48
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
SR 59230A, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >10 mg/mL, H2O: insoluble
originator
Sanofi Aventis
SMILES string
OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
InChI
1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
InChI key
XTBQNQMNFXNGLR-MKSBGGEFSA-N
Gene Information
human ... ADRB3(155)
Application
SR 59230A was used in the identification of β-adrenoceptors in rat aorta.3 It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.4
Biochem/physiol Actions
SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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