Anti-RPS3 antibody produced in rabbit

RPS3 (ribosomal protein S3) codes for a translational protein which belongs to the ribosomal small subunit protein. It is localized to the surface of 40s ribosomal subunit. The RPS3 gene is mapped to human chromosome 11q13.4. The protein belongs to the S3P family of ribosomal proteins and appears to be located in both the cytoplasm and nucleus but not in the nucleolus.

Recombinant fragment corresponding to a region within amino acids 1 and 243 of RPS3 according to NP_000996

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: Assay-dependent dilution, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms a part of the domain where translation is initiated. Studies of the mouse and rat proteins have demonstrated that the protein has an extra ribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq].
RPS3 (ribosomal protein S3) has endonuclease activity for DNA repair mechanism.

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1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

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