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SAB4200757

Anti-PLA2R1 Antibody

Name: Anti-PLA2R1 Antibody
Brand: SIGMA

mouse monoclonal, 12-6-5

Synonym(s):

Anti-180 kDa secretory phospholipase A2 receptor, Anti-C-type lectin domain family 13 member C, Anti-M-type receptor, Anti-PLA2-R, Anti-PLA2R, Anti-Secretory phospholipase A2 receptor

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

Clone:

12-6-5, monoclonal

Species reactivity:

human

Application:

FACS, IF, IHC

Citations:

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Properties

Product Name

Anti-PLA2R antibody, Mouse monoclonal, clone 12-6-5, purified from hybridoma cell culture

biological source

mouse

Quality Level

200

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

12-6-5, monoclonal

form

buffered aqueous solution

mol wt

~180 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

flow cytometry: suitable, immunoblotting: 1-2 μg/mL using partial recombinant human PLA2R1 protein (predicted ~150kDa), immunofluorescence: suitable, immunohistochemistry: suitable

isotype

IgG2b

UniProt accession no.

Q13018

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PLA2R1(22925)

Description

General description

Anti-PLA2R antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the 12-6-5 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with recombinant fragment of human PLA2R corresponding to extracellular sequence NC3. Secretory phospholipase A2 receptor (PLA2R) is 180 kDa and is a type I transmembrane glycoprotein member of the mannose receptor (MR) family. Large extracellular glycosylated region comprising an N-terminal cysteine-rich domain (CysR), a fibronectin-like type II domain (FnII), and eight to ten C-type lectin-like domains (CTLD).

Immunogen

Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3)

Application

Anti-PLA2R antibody has been used in

immunoblotting
immunofluorescence
flow Cytometry
immunohistochemistry

Biochem/physiol Actions

Secretory phospholipase A2 receptor (PLA2R) acts as a receptor for secretory phosholipase A2 (sPLA2) allowing its removal from circulation, thus regulating its biological effect. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipase A2 (sPLA2) from the blood, including group sPLA2-X and a snake venom sPLA2. The soluble circulating form of PLA2R is constitutively present as an endogenous inhibitor of sPLA2s. PLA2R is expressed in kidney podocytes of normal human glomeruli, in idiopathic membranous nephropathy (IMN) patients PLA2R is colocalized to immune deposits in glomeruli along with IgG4.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

057M4874V

51170305

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Global Trade Item Number

SKU	GTIN
SAB4200757-100UL	04061833265208