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SAB4300094

Anti-phospho-FOXO1 (pSer256) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FKH1 antibody produced in rabbit, Anti-FKHR antibody produced in rabbit, Anti-FOXO1A antibody produced in rabbit, Anti-forkhead box O1 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03791549
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Citations:
11
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

78-82 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(A-A-SP-M-D)

NCBI accession no.

NP_002006.2

UniProt accession no.

Q12778

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer256)

Gene Information

human ... FOXO1(2308)

General description

FOXO1 (forkhead box O1) is encoded by the gene mapped to human chromosome 13q14. The encoded protein is a transcription factor and is a member of the Foxo subfamily.
Transcription factor.

Immunogen

Peptide sequence around phosphorylation site of serine 256 (A-A-S(p)-M-D), according to the protein FOXO1.

Application

Anti-phospho-FOXO1 (pSer256) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

FOXO1 (forkhead box O1) blocks the differentiation of cell in fetal pancreatic progenitor cells. It controls the differentiation of adipocytes. FOXO1 is involved in the insulin regulation of glucose-6-phosphatase (G6p) expression. Additionally, this protein plays a vital role in tumor suppression by inducing growth arrest and apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
871511115

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
Huang H
Proceedings of the National Academy of Sciences of the USA, 102, 1649-1654 (2005)
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
Nakae J
The Journal of Clinical Investigation, 108, 1359-1367 (2001)
Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase
Deng X
Biochimica et Biophysica Acta, 1851, 1521-1529 (2015)
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB4300094-100UG04061833477007