SAB4502076
Anti-Parkin antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 51 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRKN2(5071)
General description
The PRKN (parkin RBR E3 ubiquitin protein ligase) gene, also referred to as PARK2, is mapped to human chromosome 6q25.2–27. It is one of the largest genes in the human genome spanning a length of 1.53Mb. The gene consists of 12 exons and encodes a protein of 465 amino acids. It is broadly expressed in several tissues, including neurons, astrocytes, lung, colon and testes.
Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Parkin.
Immunogen Range: 101-150
Immunogen Range: 101-150
Biochem/physiol Actions
The PRKN (parkin RBR E3 ubiquitin protein ligase) gene encodes an E3 ubiquitin ligase that is involved in the maintenance of dopamine (DA) neuronal homeostasis. It ubiquitinates target proteins by interacting with ubiquitin-conjugating enzymes, such as UBCH7 (Ubiquitin-conjugating enzyme E2 L3) and UBCH8 (Ubiquitin/ISG15-conjugating enzyme E2 L6). Mutations in this gene have been linked to early-onset and progression of Parkinson′s Disease. Variations in this gene have also been associated with glioblastoma and other human malignancies.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Mutations in PRKN and SNCA genes important for the progress of Parkinson?s disease.
Oczkowska A, et al.
Current Genomics, 14(8), 502-517 (2013)
Somatic mutations of the Parkinson's disease?associated gene PARK2 in glioblastoma and other human malignancies.
Veeriah S, et al.
Nature Genetics, 42(1), 77-77 (2010)
Parkin genetics: one model for Parkinson's disease.
Mata I F, et al.
Human Molecular Genetics, 13(1), R127-R133 (2004)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4502076-100UG | 04061837174377 |