SAB5701779
Anti-Phospho-AMPKβ1-S108 antibody produced in rabbit
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About This Item
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
rat, mouse, human
Application:
IHC, WB
Citations:
-
biological source
rabbit
Quality Level
antibody product type
primary antibodies
clone
polyclonal
form
liquid
species reactivity
rat, mouse, human
concentration
0.74 mg/mL
technique(s)
immunohistochemistry: 1:50-1:100, immunohistochemistry: 1:50-1:200, western blot: 1:2000-1:5000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer108)
Gene Information
human ... PRKAB1(5564)
General description
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Immunogen
A synthetic phosphorylated peptide around S108 of human AMPKβ1 (NP_006244.2).
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB5701779-100UL | 04065267675534 |