SML1073
BIX
≥98% (HPLC), molecular chaperone GRP78 inducer, powder
Synonym(s):
2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid, BiP protein Inducer X
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About This Item
Empirical Formula (Hill Notation):
C9H7NO3S
CAS Number:
Molecular Weight:
209.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
BIX, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=C(O)C=C(C(CSC#N)=O)C=C1
InChI
1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2
InChI key
SVFLBLCWKKQKDW-UHFFFAOYSA-N
Application
BIX has been used in cell viability assay.
Biochem/physiol Actions
BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.
BIX is an inducer of molecular chaperone GRP78 (BIP, Glucose regulated protein 78).
Other Notes
air sensitive
signalword
Warning
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
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Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1073-25MG | 04061832724447 |
| SML1073-5MG | 04061832724454 |