SML1497
Canrenone
≥97% (HPLC), mineralocorticoid inhibitor, powder
Synonym(s):
(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
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About This Item
Product Name
Canrenone, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
optical activity
[α]/D +17 to +24°, c = 1 in chloroform-d
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
InChI
1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
InChI key
UJVLDDZCTMKXJK-WNHSNXHDSA-N
Gene Information
human ... NR3C2(4306)
Biochem/physiol Actions
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Carc. 2 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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