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SRP4304

Sigma-Aldrich

NGF-beta from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

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Synonym(s):
Nerve Growth Factor β, Ngf, Ngfb
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized

potency

0.2 ng/mL ED50

mol wt

~13.4 kDa

packaging

pkg of 20 μg

impurities

endotoxin, tested

NCBI accession no.

P01139

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Ngf(18049)

Related Categories

General description

Nerve growth factor-β (NGF-β) belongs to the neurotrophin family. The active form of human NGF-β is a homodimer, non-glycosylated chain.

Biochem/physiol Actions

Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. It brings pro-survival effects with the help of receptor tyrosine kinase TrkA. NGF-β is associated with diabetic neuropathy and ischemic heart disease. It is also involved in airway nerve system. NGF-β is also responsible for the pain which is linked with osteoarthritis (OA). It is involved in liver fibrosis, carcinogenesis, angiogenesis and cholangiocyte proliferation.

Physical form

Lyophilized without any additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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