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T0307

Tyloxapol

BioXtra

Synonym(s):

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

CAS Number:
25301-02-4
NACRES:
NA.25
PubChem Substance ID:
24899881
UNSPSC Code:
12161900
MDL number:
MFCD00149002
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description

non-ionic

Quality Level

100

product line

BioXtra

impurities

<0.0005% Phosphorus (P)

ign. residue

<1.0%

CMC

0.018 mM

transition temp

cloud point 94.3 °C

anion traces

chloride (Cl-): <0.05%, sulfate (SO42-): <0.6%

cation traces

Al: <0.0005%, Ca: <0.0005%, Cu: <0.0005%, Fe: <0.001%, K: <0.005%, Mg: <0.0005%, NH4+: <0.05%, Na: <0.5%, Pb: <0.001%, Zn: <0.0005%

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

General description

Tyloxapol is a biocompatible surfactant
A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol has been used in a study to assess the enhanced pulmonary absorption of recombinant human insulin. It has also been used in a study to investigate the metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ1034
MKCK7328
MKCH6508
MKCF6494
MKCD4970

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Martina Theresa Hackl et al.
Nature communications, 10(1), 2717-2717 (2019-06-22)
Hepatic steatosis develops when lipid influx and production exceed the liver's ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin
Aki Uchida et al.
Frontiers in physiology, 3, 26-26 (2012-03-01)
Obesity results in abnormally high levels of triglyceride (TG) storage in tissues such as liver, heart, and muscle, which disrupts their normal functions. Recently, we found that lean mice challenged with high levels of dietary fat store TGs in cytoplasmic
S K Mehta et al.
Colloids and surfaces. B, Biointerfaces, 110, 419-425 (2013-06-12)
The equimolar mixed micellar system of Lecithin-Tyloxapol has been explored using physicochemical and spectroscopic measurements. Thermodynamic parameters have been computed for the prepared mixed micellar system. Interaction parameter, β, suggests synergistic interactions in the mixed systems. This has been further
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Global Trade Item Number

SKUGTIN
T0307-50G04061837334900
T0307-10G04061837334894
T0307-5G04061837334924