T0632
Sodium thioglycolate
≥96.5% (iodometric)
Synonym(s):
Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt
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About This Item
Linear Formula:
HSCH2COONa
CAS Number:
Molecular Weight:
114.10
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-696-4
Beilstein/REAXYS Number:
4569109
MDL number:
Quality Level
assay
≥96.5% (iodometric)
form
powder
color
white to off-white
useful pH range
6.7 (20 °C, 100 g/L)
mp
>300 °C (lit.)
solubility
water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)
storage temp.
−20°C
SMILES string
[Na+].[O-]C(=O)CS
InChI
1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
InChI key
GNBVPFITFYNRCN-UHFFFAOYSA-M
Application
Sodium thioglycolate has been used:
- as a growth supplement in enrichment media and to study its effect on Arcobacter
- in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
- in electron microscopy
Biochem/physiol Actions
Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Disclaimer
At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate
Rhodes DG, et al.
Vaccine, 33(44), 6011-6016 (2015)
Romina A Cutrullis et al.
Immunobiology, 222(2), 423-431 (2016-09-04)
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a key player in innate immunity. MIF has been considered critical for controlling acute infection by the protozoan Trypanosoma cruzi, but the underlying mechanisms are poorly understood. Our study aimed to
Kim De Paepe et al.
PeerJ, 7, e6293-e6293 (2019-02-01)
Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T0632-500G | 04061835367993 |
| T0632-100G | 04061835367979 |
| T0632-25G | 04061835367986 |