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T0656

1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril

Name: 1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril
Brand: SIGMA

Synonym(s):

Iodo-Gen^®, NSC 4462

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₀Cl₄N₄O₂

CAS Number:

51592-06-4

Molecular Weight:

432.09

NACRES:

NA.22

PubChem Substance ID:

24899904

UNSPSC Code:

12352101

MDL number:

MFCD00027367

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Properties

storage temp.

2-8°C

Quality Level

100

SMILES string

ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4

InChI

1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H

InChI key

FJQZXCPWAGYPSD-UHFFFAOYSA-N

Description

Application

Iodination reagent used in radioiodination acting as an oxidative agent

Reagent involved in comparison studies with chloramine-T

Reagent used for oxidation of urazoles

Legal Information

Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Mapping of exposed surfaces of the nicotinic acetylcholine receptor by identification of iodinated tyrosine residues.

M Mund et al.

Journal of protein chemistry, 16(3), 161-170 (1997-04-01)

Here we report on the use of iodination of the membrane-bound nicotinic acetylcholine receptor (nAChR) from Torpedo californica electric tissue in order to define surface-exposed portions of the receptor molecule. Membrane-bound nAChR was 125I-iodinated using the oxidation agent Iodo-Gen. The

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

P J Fraker et al.

Biochemical and biophysical research communications, 80(4), 849-857 (1978-02-28)

Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate.

Ganesan Vaidyanathan et al.

Nuclear medicine and biology, 29(1), 1-11 (2002-01-12)

Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular

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Global Trade Item Number

SKU	GTIN
T0656-250MG	04061833286722
T0656-1G	04061826695746