T0953
14-3-3 Tau/Theta histidine-tagged human
recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
14-3-3 tau, 14-3-3 theta, 14-3-3t, 1C5, Bap1, HS1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, YWHAQ
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About This Item
UNSPSC Code:
12352202
recombinant
expressed in E. coli
Quality Level
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~30 kDa (14-3-3 proteins)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... YWHAQ(10971)
Biochem/physiol Actions
14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. Co-immunoprecipitation experiments demonstrate the interaction of 14-3-3 τ/θ adaptor protein with various proteins (UCP3, PKCζ). 14-3-3 τ/θ is involved in cell cycle arrest and cellular differentiation. 14-3-3 τ/θ plays an active role in mediating Vpr-induced cell cycle arrest in human T cells.
Physical form
Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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14-3-3 isotypes facilitate coupling of protein kinase Cζ to Raf-1: negative regulation by 14-3-3 phosphorylation.
Van Der Hoeven, P.C., et al.
The Biochemical Journal, 15, 297-306 (2000)
Mathematical biology in Biology Direct.
Andrei Yakovlev
Biology direct, 3, 1-1 (2008-01-18)
B Pierrat et al.
European journal of biochemistry, 267(9), 2680-2687 (2000-04-28)
Uncoupling proteins (UCPs) are members of the superfamily of the mitochondrial anion carrier proteins (MATP). Localized in the inner membrane of the organelle, they are postulated to be regulators of mitochondrial uncoupling. UCP2 and 3 may play an important role
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T0953-100UG | 04061837899201 |