T6069
Thio-TEPA
Synonym(s):
N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide
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About This Item
Empirical Formula (Hill Notation):
C6H12N3PS
CAS Number:
Molecular Weight:
189.22
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
200-135-7
MDL number:
form
solid
Quality Level
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
S=P(N1CC1)(N2CC2)N3CC3
InChI
1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
InChI key
FOCVUCIESVLUNU-UHFFFAOYSA-N
General description
Chemical structure: aziridine
Application
A polyfunctional alkylating agent
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
Analysis Note
Solubility - freely soluble in water , in chloroform and in ethanol (96%)
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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J Sanz et al.
Bone marrow transplantation, 47(10), 1287-1293 (2012-02-14)
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent
Sotirios G Papageorgiou et al.
Hematological oncology, 31(1), 10-17 (2012-05-23)
Central nervous system (CNS) involvement in patients with primary mediastinal large B-cell (PMLBCL) lymphoma is a rare event, occurring in approximately 6% of patients, on the basis of the review of the literature prior to induction of Rituximab. The aim
A Fabi et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 6(2), 187-189 (1995-02-01)
Vinorelbine as single-agent has achieved an overall response rate of > 20% as second-line treatment and 40%-50% as first-line treatment. The aim of this study was to evaluate the activity and toxicity of the combination of vinorelbine and thiotepa as
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T6069-1G | 04061826759158 |