T8761
Tyloxapol
nonionic surfactant
Synonym(s):
4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane
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About This Item
CAS Number:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12161900
MDL number:
Quality Level
CMC
0.018 mM
transition temp
cloud point 94.3 °C
solubility
water: miscible
SMILES string
[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1
InChI
1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2
InChI key
GWJOFBXSBDVUMH-UHFFFAOYSA-N
General description
A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.
Application
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction. Tyloxapol is used in the development of non-ionic surfactant-based liposomes (niosomes) for use in drug delivery systems. Tyloxapol may be used to study its mechanism of protecting macrophages from endotoxins. Tyloxapol may be used to study is potential cell toxicitiy.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Zhenhua Wu et al.
International journal of molecular sciences, 19(8) (2018-08-08)
Endoplasmic reticulum (ER) stress is highly associated with liver steatosis. B-cell receptor-associated protein 31 (BAP31) has been reported to be involved in ER homeostasis, and plays key roles in hepatic lipid metabolism in high-fat diet-induced obese mice. However, whether BAP31
Jung-Hua Steven Kuo et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 208-215 (2008-03-14)
Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with
Tiago R Figueira et al.
Lipids in health and disease, 9, 146-146 (2010-12-29)
Abnormalities in lipid metabolism and transport are hallmarks in analbuminemic Nagase rats (NAR) and humans. Triglyceridemia is nearly 3- to 5-fold higher in female NAR than in control Sprague-Dawley rats (SDR). Also, NAR present with a severe plasma free fatty
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T8761-50G | 04061835550340 |