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V7127

D-Val-Leu-Lys p-nitroanilide dihydrochloride

Name: <SC>D</SC>-Val-Leu-Lys p-nitroanilide dihydrochloride
Brand: SIGMA

plasmin substrate, chromogenic, ≥98% (HPLC), powder

Synonym(s):

D-Val-Leu-Lys p-nitroanilide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₈N₆O₅ · 2HCl

Molecular Weight:

551.51

UNSPSC Code:

12352204

PubChem Substance ID:

24900765

NACRES:

NA.32

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Properties

Product Name

D-Val-Leu-Lys p-nitroanilide dihydrochloride, plasmin substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, light yellow

storage temp.

−20°C

SMILES string

Cl.[N+](=O)([O-])c1ccc(cc1)NC(=O)C(NC(=O)C(NC(=O)C(N)C(C)C)CC(C)C)CCCCN

InChI

1S/C23H38N6O5.ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);1H

InChI key

ITWYYDDNWFVYSU-UHFFFAOYSA-N

Description

Application

D-Val-Leu-Lys p-nitroanilide dihydrochloride has been used:

as substrate to measure the activity of plasminogen activator by a chromogenic assay
as a p-nitroanilide (pNA) substrate to measure the specific activities of serine protease isoforms in Gloydius intermedius venom
as a substrate in total plasmin assay using milk/cream samples

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H319,H335,H361

pcodes

P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Role of lysine binding regions in the kinetic properties of human plasmin.

J P Morris et al.

Biochemistry, 20(17), 4811-4816 (1981-08-18)

miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model.

Warren B Nothnick et al.

PloS one, 9(6), e100336-e100336 (2014-06-18)

Endometriosis is defined as the growth of endometrial glandular and stromal components in ectopic locations and affects as many as 10% of all women of reproductive age. Despite its high prevalence, the pathogenesis of endometriosis remains poorly understood. MicroRNAs, small

Feeding tannins to dairy cows in different seasons improves the oxidative status of blood plasma and the antioxidant capacity of cheese.

A Santillo et al.

Journal of dairy science, 105(11), 8609-8620 (2022-09-30)

The aim of the present study was to assess the dietary supplementation of tannins to grazing dairy cows in 2 seasons characterized by a good quality pasture (spring) or a poor-quality pasture (summer). The effects of dietary tannins were assessed

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Global Trade Item Number

SKU	GTIN
V7127-25MG	04061837481314
V7127-100MG	04061831156942
V7127-5MG	04061832918631