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WH0001111M5

Monoclonal Anti-CHEK1 antibody produced in mouse

Name: Monoclonal Anti-CHEK1 antibody produced in mouse
Brand: SIGMA

clone 2G3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CHK1, Anti-CHK1 checkpoint homolog (S. pombe)

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02262709

Conjugate:

unconjugated

Clone:

2G3, monoclonal

Application:

ELISA (i), IF

Citations:

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Properties

Quality Level

100

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2G3, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable, indirect ELISA: suitable

isotype

IgG2bκ

GenBank accession no.

BC004202

UniProt accession no.

O14757

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHEK1(1111)

Description

Immunogen

CHEK1 (AAH04202, 361 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKVWLPAT

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

07096-2G3

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Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks.

Takanori Katsube et al.

Journal of biochemistry, 156(2), 85-95 (2014-04-01)

The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent studies reported that γH2AX foci do not necessarily correlate with DSBs under other conditions. We

Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma.

Yin Xie et al.

Medical oncology (Northwood, London, England), 31(3), 844-844 (2014-01-28)

Checkpoint kinase 1 (CHEK1) is an evolutionarily conserved Ser/Thr kinase, which mediates cell-cycle arrest after DNA damage, and we previously reported that CHEK1 was overexpressed and associated with poor prognosis in hepatocellular carcinoma (HCC), indicating it was oncogenic gene. In

Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response.

Judy Yan et al.

Experimental cell research, 328(1), 132-142 (2014-08-26)

Despite the development of chemoresistance as a major concern in prostate cancer therapy, the underlying mechanisms remain elusive. In this report, we demonstrate that DU145-derived prostate cancer stem cells (PCSCs) progress slowly with more cells accumulating in the G1 phase

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Global Trade Item Number

SKU	GTIN
WH0001111M5-100UG	04061829596422