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1205003

USP

Diltiazem hydrochloride

Name: Diltiazem hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(+)-cis-Diltiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₆N₂O₄S · HCl

CAS Number:

33286-22-5

Molecular Weight:

450.98

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329749607

MDL number:

MFCD00069252

Beilstein/REAXYS Number:

4228706

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Properties

grade

pharmaceutical primary standard

API family

diltiazem

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

InChI key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P264 - P270 - P301 + P312 - P501

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[Diltiazem hydrochloride: synthetic and pharmacological studies and development].

K Abe et al.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01)

Partial lateral internal sphincterotomy versus combined botulinum toxin A injection and topical diltiazem in the treatment of chronic anal fissure: a randomized clinical trial.

Hossein Gandomkar et al.

Diseases of the colon and rectum, 58(2), 228-234 (2015-01-15)

The aim of this study is to evaluate the effectiveness and complications associated with combined topical diltiazem cream and botulinum toxin A injection versus partial lateral internal sphincterotomy in chronic anal fissure. This study is a parallel, randomized controlled trial

Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.

Takeshi Ogura et al.

Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05)

This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage. Of patients with aneurysmal SAH who underwent aneurysm repair between August 2008 and June 2011, 119

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Global Trade Item Number

SKU	GTIN
1205003-200MG	04061838714244