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1287030

USP

Furosemide Related Compound B

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-Chloro-5-sulfamoylanthranilic acid

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About This Item

Empirical Formula (Hill Notation):
C7H7ClN2O4S
CAS Number:
3086-91-7
Molecular Weight:
250.66
NACRES:
NA.24
PubChem Substance ID:
329749918
UNSPSC Code:
41116107
MDL number:
MFCD03423689
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grade

pharmaceutical primary standard

API family

furosemide

manufacturer/tradename

USP

mp

267 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1cc(Cl)c(cc1C(O)=O)S(N)(=O)=O

InChI

1S/C7H7ClN2O4S/c8-4-2-5(9)3(7(11)12)1-6(4)15(10,13)14/h1-2H,9H2,(H,11,12)(H2,10,13,14)

InChI key

QQLJBZFXGDHSRU-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Furosemide Related Compound B USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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pictograms

Environment
GHS09

hcodes

H411

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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[Determination of furosemide and its metabolic products in plasma and urine by high performance liquid chromatography and clinical application].
Y Miwa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(11), 1087-1092 (1988-11-01)
D E Smith et al.
Drug metabolism and disposition: the biological fate of chemicals, 8(5), 337-342 (1980-09-01)
The objectives of this study were to qualitatively and quantitatively compare the metabolism, pharmacokinetics, and bioavailability of furosemide in healthy volunteers after intravenous and oral administration. We also determined the plasma protein binding of furosemide in vivo after iv administration.
G M Hanna et al.
Journal of AOAC International, 76(3), 526-530 (1993-05-01)
A simple, specific, and accurate proton nuclear magnetic resonance (1H-NMR) spectroscopic method has been developed for the identification and assay of furosemide and its degradation product, 4-chloro-5-sulfamoylanthranilic acid (CSA), in tablets and injections. Dissolution of the sample in D2O-NaOD resulted
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Global Trade Item Number

SKUGTIN
1287030-100MG04061833850350