V900497
Pepsin from porcine gastric mucosa
Vetec™, reagent grade
Synonym(s):
Pepsin A, Pepsin from hog stomach
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About This Item
CAS Number:
UNSPSC Code:
12352204
EC Number:
232-629-3
MDL number:
Specific activity:
400-800 units/mg protein
grade
reagent grade
product line
Vetec™
form
solid
specific activity
400-800 units/mg protein
mol wt
35 kDa
Application
Pepsin cleavage can be used to produce F(ab′)2 fragments of antibodies. pepsin at www.sigma-aldrich.com/enzymeexplorer.
Biochem/physiol Actions
Preferential cleavage: hydrophobic and aromatic residues in P1 and P1′ postitions. Cleaves Phe-Val, Gln-His, Glu-Ala, Ala-Leu, Leu-Tyr, Tyr-Leu, Gly-Phe, Phe-Phe and Phe-Tyr bonds in the β chain of insulin
Analysis Note
Optimum pH is 2-4. Active in 4 M urea and 3 M guanidine HCl. Stable at 60 °C. Pepsin is irreversibly inactivated at pH 8.0 - 8.5.
Other Notes
One unit will produce a change in A280 of 0.001 per minute at pH 2.0 at 37 deg C, measured as TCA-Soluble products using hemoglobin as substrate.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| V900497-100G | 04061832708706 |
| V900497-500G | 04061832708713 |