Merck
CN
HomeProductsPharma & Biopharma ManufacturingBuffer & Media PrepBuffers & pH Adjusters

Buffers & pH Adjusters

Buffer and pH Adjuster

Buffer quality is vital for the success of biopharmaceutical processes, as well as small molecule formulation, because buffers are indispensable in nearly every production step. Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP production to manufacturing according to GMP guidelines including excipients specifically for drug formulation and including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters backed by extensive regulatory support.

  • All products manufactured under appropriate controls
  • Multi-compendial, where applicable
  • Low bioburden and endotoxin levels
  • Low UV-absorbance of aqueous solutions
  • Comprehensive documentation and regulatory support

Related Product Resources

Article: Reproducibility with Biological Buffers
Brochure: Your Partner for Liquid Dose Applications
Formulation Product Finder
Pharmaceutical Application Guide
Reproducibility with Biological Buffers
Tech Brief: Holistic Buffer Preparation

Webinar: High-Throughput Process Development: Utilizing the Full Potential of Miniature Chromatography Columns
Webinar: Combined pH/Salt Gradients for the Separation of Challenging Protein Variants
Webinar: Getting Your Buffers Right: How to Control the pH of Cell Culture Medium
Buffer Reference Center
Product Guide: Raw Materials for Biopharmaceutical Manufacturing

Products

Sort by Relevance
Showing 1-20 of 77
Change View
Showing 1-20 of 77
Compare
Product Number
Product Name
Product Description
Pricing
1.04352
L-Histidine
EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP
1.08219
Tris(hydroxymethyl)aminomethane hydrochloride
EMPROVE® EXPERT
1.06345
Sodium dihydrogen phosphate dihydrate
EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JPE, USP, E 339
1.06585
di-Sodium hydrogen phosphate
anhydrous, EMPROVE® ESSENTIAL, Ph. Eur., BP, JPE, USP, E 339
1.08386
Tris(hydroxymethyl)aminomethane
(Trometamol), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP
1.37042
TRI-SODIUM CITRATE DIHYDRATE
crystalline, EMPROVE® EXPERT, Ph. Eur., BP, JP, USP, ACS
1.37055
Hydrochloric acid
4 mol/l, EMPROVE® EXPERT
1.37007
Hydrochloric acid
fuming 37%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, NF
1.04354
L-Histidine monohydrochloride monohydrate
EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP
PHG0005
BIS-TRIS propane
1.06349
Sodium dihydrogen phosphate monohydrate
EMPROVE® ESSENTIAL, BP, ChP, USP
1.06573
di-Sodium hydrogen phosphate dodecahydrate
crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP
1.06576
di-Sodium hydrogen phosphate dihydrate
EMPROVE® ESSENTIAL, Ph. Eur., BP, USP
1.28205
Sodium acetate trihydrate
EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP
RES6007H-A7
HEPES sodium salt
PHG0001
HEPES
1.08307
Tris(hydroxymethyl)aminomethane
(Trometamol) high purity, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP
1.00056
Acetic acid
(glacial) 100%, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, E 260
1.06574
di-Sodium hydrogen phosphate heptahydrate
EMPROVE® ESSENTIAL, DAC, USP
1.37036
di-Sodium hydrogen phosphate dihydrate
EMPROVE® EXPERT, Ph. Eur., BP, USP
You have viewed 1-20 of 77 results
Page 1 of 4
Page 1  of 4

We cover all commonly used buffering systems such as phosphates, acetates, and citrates, as well as customized buffers and organic buffers that include TRIS, HEPES, MES, BIS-TRIS, PBS, imidazole, and many more. If you need a global supply partner capable of fast, flexible turnaround, our manufacturing locations around the world can provide high-quality biological buffers manufactured according to GMP guidelines, in quantities from a gram to metric ton scale.

Ensuring Reproducibility while Minimizing Risk

All buffering products use qualified, high-purity raw materials of defined specifications to ensure reproducible processing, manufactured with processes that are designed to minimize microbiological contamination and concentrations. Consequently, drug manufacturers worldwide rely on our products for:

  • Formulating any kind of liquid medicinal product for oral, topical, ophthalmic, otic, inhalative, or nasal administration
  • Optimizing pH and other upstream process parameters to obtain needed product characteristics
  • Maintaining defined purification conditions downstream to stabilize valuable proteins and protect against contamination

Speeding you Through the Regulatory Maze

As part of our Emprove® Chemicals portfolio, buffers and pH adjusters are supported with comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve processes.

Related Product Categories
Pyrogen Testing
Pyrogen testing is a critical step in ensuring the safety of parenteral pharmaceutical products and medical devices. The Monocyte Activation Test (MAT) is an in vitro pyrogen test that can detect both endotoxin and non-endotoxin pyrogens in one test.
Cleaning In Place
Our tailor-made, top-quality Cleaning in Place (CIP) solutions help you save time, money, and effort. Instead of preparing your own solutions, simply order the volumes and concentrations you require from our GMP process solutions plant – then integrate them into your own processes.
Excipients for Your Liquid Application
Whether you are developing solutions, emulsions or suspensions – we provide high-quality pharmaceutical excipients for liquid formulations.
Biopharmaceutical Formulation
Specifically developed for high-risk biopharmaceutical applications, our high-quality process chemicals and excipients help you to minimize the regulatory and quality-associated risks of biomolecule formulation.
Virus Filter Holders and Systems
Flexible, easy-to-use filter holders are a key component for integration of the Viresolve® Pro Solution, enabling scalable virus filtration that meets your manufacturing demands.
Sterile Filtration and Bioburden Control
Browse our products for bioprocessing sterile filtration and bioburden control including liquid and gas sterile filters, as well as integrity testers.
Bioprocessing Liquid Cell Culture Media & Buffers
We offer the industry’s highest quality sterile liquid capabilities, supplying ready-to-use cell culture media, buffers, CIP and SIP products from GMP facilities worldwide to optimize your biopharma production.
Related Applications
Sterile Filtration Strategies
It is critical for drug products to be free from bacteria and other microorganisms in order to ensure patient safety. Learn how expertise in filtration processes can meet the challenge, using solutions such as aseptic filtration on pharmaceutical products that cannot be terminally sterilized.
Related Services
Emprove® Program
Confidently speed your way through the regulatory maze and fast track your new drug to market with the Emprove® Program. High-quality products, comprehensive documentation, and superior customer support facilitate your efforts in qualification, risk assessment, and process optimization.
Buffer Calculator
Calculate buffer molarity and get buffer solution recipes for Tris, sodium phosphate, and many others. Concentrations can be calculated by molarity or percentage. This buffer calculator provides empirical formula, pKa, buffer pH range, and formula weight.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?