Cancer research

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The Comet Assay, also called single cell gel electrophoresis (SCGE), is a sensitive and rapid technique for quantifying and analyzing DNA damage in individual cells.

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative

Folic Acid Metabolism: A Role in Cancer's Cause and Cure

This article reviews some of our newest and most innovative technologies and their specific applications toward cancer research. It describes how complex the disease of cancer is, and how difficult it is to identify one topic that is completely

ABC Transporters and Cancer Drug Resistance

We presents an article on ABC Transporters and Cancer Drug Resistance

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

Long-Term Live Cell Tracking of Cancer and Stem Cells Using a Biocompatible Fluorescent Nanoparticle Based Upon Aggregation Induced Emission (AIE Dot) Nanotechnology

Biocompatible organic fluorescent nanoparticles (AIE Dots) that can be used to label cells and vasculature for long-term live cell tracking and tracing experiments.

Hypoxia Detection Assays

Hypoxia detection assays to measure oxygen levels in both live and fixed cells and tissues.

Cell Migration & Invasion Assays

Metastasis is the cumulative result of multiple changes in tumor cells. Explore tumor metastasis employing various cell migration and invasion assays like Boyden chamber assay, Millicell® µ-Migration Assay and in vitro scratch assay.

Application of Corning® CellSTACK®-5 Chamber with the Corning CellBIND® Surface to Simplify and Enhance Mass-Production of Recombinant Proteins

Discover how the Corning CELLSTACK-5 Chamber is used to simply and enhance the mass production of recombinant proteins.

Cancer Stem Cell Proliferation in Human Prostate and Breast Cancer Cell Lines Utilizing a New Defined Serum-Free 3D Spheroid Media

Serum-free defined cancer stem cell media used to grow and expand cancer cells in 3D tumorsphere aggregates.

Ginseng (Panax quinquefolius) Augments Doxorubicin-Induced Inhibition of Human Breast Cancer Cell Proliferation and Tumor Growth: Mechanisms of Action

Ginseng root extract inhibits the proliferation of human cancer cells in vitro, including those that represent many common cancers, such as breast cancer. Ginseng extracts contain over 20 different ginsenosides, saponin glycosides that are biologically active constituents of ginseng. Several

Angiostatin and Endostatin: Key Players in a Dual Threat Approach to Cancer Treatment

Anticancer drugs development - natural and synthetic angiogenesis inhibitors.

Epidermal growth factor receptor (EGFR) signaling

Read review on EGF/EGFR signaling (epidermal growth factor receptor) and find links to related products at sigmaaldrich.com

Immunohistochemistry: Current Applications in Breast Cancer

Immunohistochemistry (IHC) is used to characterize intracellular proteins or various cell surfaces in all tissues. Individual markers or more often panels of various marker proteins can be used to characterize various tumor subtypes, confirm tissue of origin, distinguish metastatic from

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Angiogenesis Assays

Cell based angiogenesis assays to analyze new blood vessel formation for applications of cancer research, tissue regeneration and vascular biology.

Fibroblast Growth Factor Family (FGF)

Fibroblast growth factors in cell culture and various growth factors for your research

Co-culture of Tumor and Stromal Cells in TrueGel3D™ Hydrogels

TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.

Primary Cell Culture Basics

What are primary cells? A comprehensive overview of animal and human primary cell lines and media and how they are used in biomedical cell culture applications. Primary cultures are less homogeneous relative to cell lines.

Dynamic Live Cell Imaging of Caspase Mediated Apoptosis and Cellular Hypoxia in Lymphocytes and Cancer Cells Using the CellASIC® ONIX2 Microfluidic Platform

Application note on how the CellASIC® ONIX2 microfluidic system can be used to analyze caspase-3 mediated apoptosis/cell death and cellular hypoxia in live immune and cancer cell lines.

Apoptosis Assays

Cellular apoptosis assays to detect programmed cell death using Annexin V, Caspase and TUNEL DNA fragmentation assays.

Epigenetics Overview

Epigenetics is a term coined to describe changes that are not mutation based but can still be passed on from generation to generation. Genes that are activated or repressed without any change in DNA sequence are epigenetically controlled. Epigenetic modifications

Carcinogenesis and Epigenetics

Applications of Cytokines and Growth Factors in Cancer Research

Cell Tracking with Lipophilic Membrane Dyes

Optimal staining is a key component for studying tumorigenesis and progression. Learn useful tips and techniques for dye applications, including examples from recent studies.

Fatty Acid Synthesis and Metabolism in Cancer Cells

Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are

Studies of Dimerization and Activation of Receptors in the EGFR-Family Using Duolink® Assays

Our aim was to investigate the dimerization and activation pattern of two receptors, EGFR (ErbB1) and HER2 (ErbB2), in the EGFR-family using breast cancer cell lines and selected colon tissues as model systems.

NF-κB and Inflammation

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed

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