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183938

2,3,5,6-四甲基吡嗪

Name: 2,3,5,6-四甲基吡嗪
Brand: ALDRICH

98%

别名:

2,3,5,6-四甲基吡嗪, 四甲基吡嗪碱, 川芎嗪

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关于此项目

经验公式（希尔记法）:

C₈H₁₂N₂

化学文摘社编号:

1124-11-4

分子量:

136.19

NACRES:

NA.22

PubChem Substance ID:

24851081

eCl@ss:

39161809

UNSPSC Code:

12352100

EC Number:

214-391-2

MDL number:

MFCD00006146

Beilstein/REAXYS Number:

113100

Assay:

98%

Form:

solid

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属性

Quality Level

100

assay

98%

form

solid

bp

190 °C (lit.)

mp

77-80 °C (lit.)

SMILES string

Cc1nc(C)c(C)nc1C

InChI

1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

InChI key

FINHMKGKINIASC-UHFFFAOYSA-N

说明

General description

2,3,5,6-四甲基吡嗪是从麻黄中分离得到的。它可用于治疗多种疾病，如哮喘、心力衰竭、鼻炎和尿失禁。它是烟草的一种香味成分。其与 4-羟基苯甲酸形成共晶，表现出超分子合成子多晶型。

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.

Gyoseon Goya M Yeom et al.

International immunopharmacology, 18(2), 262-269 (2013-12-18)

2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and

Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine.

B R Sreekanth et al.

Chemical communications (Cambridge, England), (23)(23), 2375-2377 (2007-09-12)

Co-crystals of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine (2 : 1) exhibit the first supramolecular synthon polymorphism in a co-crystal; metastable anti-hierarchic polymorph I converts to stable hierarchic form II.

Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.

Xian-Chao Cheng et al.

Bioorganic & medicinal chemistry, 17(8), 3018-3024 (2009-03-31)

A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged

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全球贸易项目编号

货号	GTIN
183938-100G	04061838346681
183938-25G	04061838756435