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402168

6-溴-3-甲酰色酮

Name: 6-溴-3-甲酰色酮
Brand: ALDRICH

99%

别名:

6-溴-4-氧代-4H-1-苯并吡喃-3-甲醛

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关于此项目

经验公式（希尔记法）:

C₁₀H₅BrO₃

化学文摘社编号:

52817-12-6

分子量:

253.05

NACRES:

NA.22

PubChem Substance ID:

24865055

UNSPSC Code:

12352100

MDL number:

MFCD00191849

Assay:

99%

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属性

Quality Level

100

assay

99%

mp

190-193 °C (lit.)

functional group

aldehyde, bromo, ketone

SMILES string

[H]C(=O)C1=COc2ccc(Br)cc2C1=O

InChI

1S/C10H5BrO3/c11-7-1-2-9-8(3-7)10(13)6(4-12)5-14-9/h1-5H

InChI key

PCEZXSJBHMOQFT-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

说明

General description

6-Bromo-3-formylchromone (6-Bromo-4-oxo-4H-1-benzopyran-3-carboxaldehyde) is a 3-formylchromone derivative. In vivo cytotoxic activity of 6-bromo-3-formylchromone against normal and tumor cells has been tested.

Application

6-Bromo-3-formylchromone may be used in the preparation of 6′-bromopyranothiazine-4,7-diones.

6-Bromo-3-formylchromone is the suitable reagent used in a study to investigate the multidrug resistance reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It may be used in the preparation of chromone containing sulfonamides.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

Mariya al-Rashida et al.

Bioorganic & medicinal chemistry, 19(11), 3367-3371 (2011-05-11)

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities

A study of the reactions of 2-aryl-4-hydroxy-6H-1,3-thiazin-6-ones with chromone-3-carboxaldehydes.

Shutov RV, et al.

Tetrahedron Letters, 52(2), 266-269 (2011)

Biological activity of 3-formylchromones and related compounds.

Masami Kawase et al.

In vivo (Athens, Greece), 21(5), 829-834 (2007-11-21)

Several 3-formylchromone derivatives were examined for their tumor cell-cytotoxic, anti-Helicobacter pylori, urease inhibitory and anti-HIV activity. Comparing their relative cytotoxicity against four human tumor cell lines and three normal human cells, tumor cell-specific cytotoxicity was detected in some 3-formylchromone derivatives.

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全球贸易项目编号

货号	GTIN
402168-1G	04061831985801