Merck
CN
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文件

408719

Sigma-Aldrich

支化聚乙烯亚胺

average Mw ~800 by LS, average Mn ~600 by GPC

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别名:
PEI, 支化乙二胺
线性分子式:
H(NHCH2CH2)nNH2
CAS号:
25987-06-8
MDL编号:
MFCD00084427
NACRES:
NA.23

形式

viscous liquid

分子量

average Mn ~600 by GPC
average Mw ~800 by LS

折射率

n20/D 1.5240

密度

1.050 g/mL at 25 °C

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI key

SFLOAOINZSFFAE-UHFFFAOYSA-N

相关类别

一般描述

聚乙烯亚胺是一种亲水性聚合物，作为一种非病毒合成载体，广泛用于体内递送治疗性核酸。由于其优异的理化性质，它被应用于蛋白质的分离和纯化、二氧化碳吸收、药物载体、废水处理、生物标记等多个领域。

应用

支链型PEI可作为前体合成共轭多聚体，用于高效基因转染。PEI与Jeffamine聚醚的共轭化和PEI氨基的胍化可降低多聚体的细胞毒性，并保护其在血清蛋白存在下不会发生聚焦。

PEI 浸渍竹炭可用作CO2吸附剂。PEI中存在大量的氨基基团，可在酸碱作用下与CO2发生反应，增强竹炭的吸附能力。

它还可用于制备对有机药物分子具有高配位能力的交联水溶性聚合物。

特点和优势

  • 支链型PEI具有较好的络合 能力和缓冲能力。
  • 高离子交换 能力和对蛋白质的亲和力。
  • 显著的DNA转移效率。

外形

支化聚合物

警示用语：

Danger

危险声明

H302 - H318 - H411

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

356.0 °F

闪点(°C)

180 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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