form
pellets
Quality Level
feed ratio
lactide:glycolide 65:35
mol wt
PEG Mn 2,000, PLGA Mn 4,500, average Mn 6,500 (total)
degradation timeframe
1-4 weeks
transition temp
Tm 241-246 °C
PDI
≤2.0
storage temp.
2-8°C
General description
两亲性嵌段共聚物 (AmBC) 由两种化学结构不同的均聚物嵌段组成。其中一个是亲水性的，另一个是疏水性的。这些大分子在水性介质中溶解时具有自组装的属性。PEG-PLGA 是一种最常用的可生物降解的两亲性嵌段共聚物，用于药物输送。PEG 是亲水性部分，PLGA 是疏水性部分。
Application
用于合成用于药物差异递送和控释的靶向纳米粒子。
形成“隐形”聚乙二醇化微粒
Features and Benefits
- 生物相容性好，免疫原性低，可降解性好。
- 通过改变嵌段共聚物链段大小以适应特定的应用，可以很容易地调节性质。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 764825-1G | 04061832923147 |