901558
来那度胺
≥95%
别名:
1-氧-4-氨基-2-（2,6-二氧哌啶-3-基）异吲哚, 3-（4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基）-2,6-哌啶二酮, 3-（4-氨基-1-氧代异吲哚-2-基）哌啶-2,6-二酮, E3连接酶配体, 用于PROTAC® >研究的配体
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关于此项目
经验公式（希尔记法）:
C13H13N3O3
化学文摘社编号:
分子量:
259.26
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
powder
ligand
lenalidomide
assay
≥95%
form
powder
reaction suitability
reagent type: ligand
mp
265-268 °C
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
InChI
1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Application
来那度胺被证明是一种可与Cereblon（CRBN）蛋白结合的配体。来那度胺和其他沙利度胺衍生物可用于构建用于靶向蛋白质降解和 PROTAC（靶向蛋白降解嵌合体）技术的小分子。 探索 蛋白质降解剂合成砌块，E3连接酶配体-Linker结合物简化了PROTAC的合成和文库生成。
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Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1B - STOT RE 2
target_organs
Blood
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.