936499
3-Pyridinecarboxylic acid, 6-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-
≥95%
别名:
6-[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-3-pyridinecarboxylic acid
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Quality Level
assay
≥95%
form
powder or crystals
color
light yellow to dark yellow
storage temp.
2-8°C
SMILES string
O=C(O)C1=CN=C(C=C1)N2CCN(C3=CC=C4C(=O)N(C(=O)C4=C3)C5C(=O)NC(=O)CC5)CC2
InChI
1S/C23H21N5O6/c29-19-6-4-17(20(30)25-19)28-21(31)15-3-2-14(11-16(15)22(28)32)26-7-9-27(10-8-26)18-5-1-13(12-24-18)23(33)34/h1-3,5,11-12,17H,4,6-10H2,(H,33,34)(H,25,29,30)
InChI key
MZYKMQYHJGPMEI-UHFFFAOYSA-N
Application
This is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
- Targeted Protein Degradation by Small Molecules
- Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
- Small-Molecule PROTACS: New Approaches to Protein Degradation
- Targeted Protein Degradation: from Chemical Biology to Drug Discovery
- Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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