H8520
(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐
≥98%
别名:
(±)-2-二丙基氨基-8-羟基-1,2,3,4-四氢萘, (±)-8-Hydroxy-2-(dipropylamino)tetralin, (±)-8-OH-DPAT
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关于此项目
经验公式（希尔记法）:
C16H25NO · HBr
化学文摘社编号:
分子量:
328.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98%
Quality Level
assay
≥98%
SMILES string
Br[H].CCCN(CCC)C1CCc2cccc(O)c2C1
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H
InChI key
BATPBOZTBNNDLN-UHFFFAOYSA-N
Application
(±)-8-羟基-2-（二丙基氨基）四氢溴酸盐是一种强效的选择性 5-羟色胺 (5HT 1A )-受体激动剂 ，通常作为药理学研究的标准。
Biochem/physiol Actions
选择性 5-HT1 激动剂，对亚型 5-HT1A 受体具有高亲和性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Arylpiperazine agonists of the serotonin 5-HT 1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.
Stroth N, et al.
Bioorganic & Medicinal Chemistry, 23(15), 4824-4830 (2015)
8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
L E Arvidsson et al.
Journal of medicinal chemistry, 24(8), 921-923 (1981-08-01)
S J Peroutka
Journal of neurochemistry, 47(2), 529-540 (1986-08-01)
Drug interactions with 5-HT1 (5-hydroxytryptamine type 1) binding site subtypes were analyzed in rat frontal cortex. 8-Hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) displays high affinity (Ki 3.3 +/- 1 nM) for 29 +/- 3% of total [3H]5-HT binding in rat frontal cortex and low
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H8520-100MG | 04061833810699 |
| H8520-25MG | 04061833810705 |