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1.37004

Titriplex® III

(ethylene dinitrilo tetraacetic acid disodium salt dihydrate), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

别名:

乙二胺四乙酸 二钠盐 二水合物, EDTA 二钠盐, EDTA-Na2, 乙二胺四乙酸Na2, 乙二胺四乙酸盐 二钠盐 二水合物, 二钠乙二胺四乙酸盐 二水合物, 依地酸钙钠

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关于此项目

经验公式（希尔记法）:
C10H14N2Na2O8 · 2H2O
化学文摘社编号:
6381-92-6
分子量:
372.24
UNSPSC Code:
12352107
EC Index Number:
205-358-3
Beilstein/REAXYS Number:
3900609
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grade

ACS reagent

Quality Level

500

agency

BP, ChP, JP, Ph. Eur., USP

product line

EMPROVE® EXPERT

form

solid

feature

RNase and DNase free

technique(s)

in vitro transcription (IVT): suitable

pH

4-5 (20 °C, 50 g/L in H2O)

mp

248 °C (dec.) (lit.)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

no temp limit

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Titriplex® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics. The disodium salt provides improved solubility in water compared to standard EDTA.


Due to its low microbial and endotoxin limits, Titriplex® III (ethylene dinitrilo tetraacetic acid disodium salt dihydrate) Emprove® Expert is especially suitable for high-risk applications.
二价阳离子的螯合剂。 对需要二价阳离子发挥活性的酶，比如金属蛋白酶具有抑制作用。

Other Notes

Elimination of water of crystallization: 110 °C

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Titriplex is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H332,H373

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

target_organs

Respiratory Tract

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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