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196870

Bay 11-7082

≥98% (HPLC), solid, NF-kB/TNF-α inhibitor, Calbiochem

别名:

Bay 11-7082

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关于此项目

经验公式（希尔记法）:
C10H9NO2S
化学文摘社编号:
19542-67-7
分子量:
207.25
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00712162
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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产品名称

Bay 11-7082, The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c1ccc(cc1)C)\C=C\C#N

InChI

1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

InChI key

DOEWDSDBFRHVAP-KRXBUXKQSA-N

General description

潜在抗炎药。选择性和不可逆地抑制TNFα诱导的IκBα磷酸化（IC50 = 10 µ M），而不影响组成型IκB-α 磷酸化。减少NFκB的核易位并抑制TNFα诱导的内皮-白细胞粘连分子E-选择素、VCAM-1和ICAM-1的表面表达。E-选择素的抑制作用是不可逆的（IC50 ~10 µM）。还可以可逆地增加p38激酶和JNK-1的活性，并刺激130-140 kDa蛋白的酪氨酸磷酸化。
选择性和不可逆地抑制TNFα诱导的IκBα磷酸化（IC50 = 10 µ M）的潜在抗炎药，导致NF-κB和粘连分子的表达降低。不影响组成型IκBα自磷酸化。抑制TNFα诱导的内皮-白细胞粘连分子E-选择素、VCAM-1和ICAM-1的表面表达。还提供了100 mM（10 mg/483 µl）BAY 11-7082（目录编号196871）的DMSO溶液。

Biochem/physiol Actions

主要靶标
TNF-α诱导的IκB磷酸化α
可逆：否
细胞可渗透性：是
靶标IC50：10 µM，抑制TNF-α-诱导的IκB磷酸化α

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。

Other Notes

Kamthong PJ. and Wu, M-C. 2001.Biochem.J. 356.
Izban, K.F., et al. 2000.Hum.Pathol.31, 1482.
Pierce, J.W., et al. 1997.J. Biol. Chem. 272, 21096.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

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存储类别

11 - Combustible Solids

wgk

WGK 3

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全球贸易项目编号

货号GTIN
196870-10MG04055977206562