553502
NSC23766 trihydrochloride
≥93% (HPLC), lyophilized, Rac1 inhibitor, Calbiochem®
别名:
NSC23766, Rac1抑制剂
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关于此项目
经验公式（希尔记法）:
C24H38Cl3N7
化学文摘社编号:
分子量:
530.96
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥93% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
Rac1抑制剂, Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC50 ~50 µM).
Quality Level
assay
≥93% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Cl.Cl.Cl.N(CCCC(Nc1nc(cc(n1)C)Nc2cc3c(nc(cc3N)C)cc2)C)(CC)CC
InChI
1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
InChI key
CPUHORIUXPQCHW-UHFFFAOYSA-N
General description
一种细胞渗透性嘧啶化合物，通过干扰Rac1和Rac特异性GEF（鸟嘌呤核苷酸交换因子）Trio和Tiam1（IC50 ~50 µM）之间的相互作用，特异性和可逆地抑制Rac1 GDP/GTP交换活性。显示有效抑制NIH3T3和PC-3细胞中Rac1介导的细胞功能（有效剂量~50至100 μM）。对Cdc42或RhoA激活无影响，且不影响Rac1与BcrGAP或PAK1的相互作用。减少TRAP诱导和胶原刺激的血小板聚集（IC50分别为50 mM和64 mM）。
Biochem/physiol Actions
主要靶标
Rac1
Rac1
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：针对Rac1 GDP/GTP交换活性约为50µM；针对TRAP诱导和胶原蛋白刺激的血小板聚集为50 mM和64 mM
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Dwivedi, S., et al. 2010.J. Translational Med.8, 128.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable