Merck
CN
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文件

安全信息

14366C

SAFC

EX-CELL® Advanced CHO Fed-batch培养基

liquid

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NACRES:
NA.75

无菌性

sterile-filtered

质量水平

500

形式

liquid

technique(s)

cell culture | mammalian: suitable (suspension)

组分

L-glutamine: no

运输

ambient

储存温度

2-8°C

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相关类别

一般描述

EX-CELL® AdvancedCHO Fed-batch Medium is chemically-defined and contains no animal derived components. This newest platform from SAFC has been specifically developed to support growth and productivity across a diverse set of Chinese Hamster Ovary (CHO) cells in fed-batch cultures while still allowing for flexibility in the adjustment of protein quality attributes. This contemporary fed-batch platform was developed using a strategy of Multivariate Analysis to establish correlations in which the formulation components influence critical process and product attributes such as titer, fold expansion, receptor expression, and glycosylation. This platform contains no hypoxanthine and thymidine, L-glutamine, phenol red or 2-mercaptoethanol (2-ME). This medium is intended to be a part of a fed-batch platform, and used with EX-CELL® Advanced CHO Feed 1 (24367C - with glucose or 24368C - without glucose).
EX-CELL® AdvancedCHO Fed-batch培养基化学性质明确且不含有动物来源成分。这种来自SAFC的最新平台专门用于支持补料分批培养中多种中国仓鼠卵巢（CHO）细胞的生长和生产力，同时实现对蛋白质质量属性的调整灵活性。这种现代的补料分批平台是使用多变量分析策略而开发以建立相关性的，其中配方组分可影响关键过程和产品属性，如滴度、倍数扩增、受体表达和糖基化。 该平台不含有次黄嘌呤和胸苷、L-谷氨酰胺、酚红或2-巯基乙醇（2-ME）。

该培养基旨在成为补料分批平台的一部分，并与EX-CELL ®Advanced CHO Feed 1（24367C-含有葡萄糖或24368C-不含葡萄糖）同时使用。

包装

14366C-1000ML

联系

提交EX-CELL Advanced CHO Fed-batch申请表以与SAFC代表取得联系。

法律信息

EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

相关产品

产品编号
说明
价格

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

动植物来源培养基

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Weiyi Liu et al.
Biotechnology progress, 37(1), e3061-e3061 (2020-08-05)
Antibody-dependent cellular cytotoxicity (ADCC) is the primary mechanism of actions for several marketed therapeutic antibodies (mAbs) and for many more in clinical trials. The ADCC efficacy is highly dependent on the ability of therapeutic mAbs to recruit effector cells such

商品

EX-CELL® Advanced™ CHO Fed-Batch System – Bioprocessing Technology Institute, Singapore Case Study

In this study, nine commercially available, chemically defined media and feed combinations from different vendors were assessed for producing monoclonal antibody in Chinese hamster ovary (CHO) cells.

EX-CELL® Advanced™ CHO Fed-Batch System – Bioprocessing Technology Institute, Singapore Case Study

In this study, nine commercially available, chemically defined media and feed combinations from different vendors were assessed for producing monoclonal antibody in Chinese hamster ovary (CHO) cells.

Preparing CHO Cells for Higher Productivity by Optimizing a Perfused Seed Train

This application note describes the benefits and performance of Cellvento® 4CHO-X Expansion Medium designed for multiple cell expansion steps from vial thaw to N-1 stages to generate higher biomass for inoculating fed-batch production bioreactors

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