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57180

Indo 1

Name: Indo 1
Brand: SIGMA

suitable for fluorescence, ≥80.0% (HPLC)

别名:

4-(6-Carboxy-2-indolyl)-4′-methyl-2,2′-(ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid pentapotassium salt

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关于此项目

经验公式（希尔记法）:

C₃₂H₂₆K₅N₃O₁₂

化学文摘社编号:

132319-56-3

分子量:

840.05

NACRES:

NA.32

PubChem Substance ID:

329758276

UNSPSC Code:

12352200

MDL number:

MFCD00077797

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属性

assay

≥80.0% (HPLC)

form

solid

fluorescence

λ_ex 331 nm; λ_em 398 nm in 0.1 M Tris pH 8.0, 10 mM Ca²⁺, λ_ex 349 nm; λ_em 482 nm (100mM KCI)

suitability

in accordance for fluorescence, suitable for fluorescence

storage temp.

−20°C

SMILES string

[K+].[K+].[K+].[K+].[K+].Cc1ccc(N(CC([O-])=O)CC([O-])=O)c(OCCOc2cc(ccc2N(CC([O-])=O)CC([O-])=O)-c3cc4ccc(cc4[nH]3)C([O-])=O)c1

InChI

1S/C32H31N3O12.5K/c1-18-2-6-24(34(14-28(36)37)15-29(38)39)26(10-18)46-8-9-47-27-13-20(5-7-25(27)35(16-30(40)41)17-31(42)43)22-11-19-3-4-21(32(44)45)12-23(19)33-22;;;;;/h2-7,10-13,33H,8-9,14-17H2,1H3,(H,36,37)(H,38,39)(H,40,41)(H,42,43)(H,44,45);;;;;/q;5*+1/p-5

InChI key

VGZPRMSXVNDMAN-UHFFFAOYSA-I

说明

Application

Indo 1, a fluorescent calcium chelator and indicator, is used to monitor cytoplasmic Ca2+ transients induced by various physiological and mechanical processes.

Other Notes

Fluorescent calcium chelator and indicator with an unusually large shift in fluorescence emission from 480 nm to 400 nm on binding of calcium. Useful for intracellular application

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Fluorescence Lifetime Measurement

Fluorescence lifetime measurement is advantageous over intensity-based measurements. Applications include fluorescence lifetime assays, sensing and FLI.

Indo-1 derivatives for local calcium sensing.

Michael Bannwarth et al.

ACS chemical biology, 4(3), 179-190 (2009-02-06)

The role of calcium in signal transduction relies on the precise spatial and temporal control of its concentration. The existing means to detect fluctuations in Ca2+ concentrations with adequate temporal and spatial resolution are limited. We introduce here a method

Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: analysis with indo-1.

M K Bijsterbosch et al.

Biochemical and biophysical research communications, 137(1), 500-506 (1986-05-29)

The new Ca2+-probe indo-1 has a high fluorescence intensity, which allows low intracellular dye loadings. Stimulation of indo-1-loaded mouse B cells with anti-Ig antibodies provoked rapid rise of free cytoplasmic Ca2+ from 100 nM to greater than 1 microM, followed

Microsphere-based real-time calcium sensing.

Rosario M Sánchez-Martín et al.

Angewandte Chemie (International ed. in English), 45(33), 5472-5474 (2006-07-19)

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全球贸易项目编号

货号	GTIN
57180-1MG-F	04061823354684
57180-5MG-F	04061832532691