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75199

阿齐霉素

Name: 阿齐霉素
Brand: SIGMA

broad-spectrum antimicrobial agent, powder

别名:

CP 62,993

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关于此项目

经验公式（希尔记法）:

C₃₈H₇₂N₂O₁₂

化学文摘社编号:

83905-01-5

分子量:

748.98

UNSPSC Code:

12352200

PubChem Substance ID:

329766256

NACRES:

NA.77

MDL number:

MFCD00873574

Form:

powder

Quality level:

200

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属性

产品名称

阿齐霉素,

form

powder

Quality Level

200

optical activity

[α]/D −45±2°, c = 1% in ethanol

antibiotic activity spectrum

viruses

application(s)

environmental

mode of action

protein synthesis | interferes

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI key

MQTOSJVFKKJCRP-BICOPXKESA-N

说明

General description

Azithromycin is a hydrophobic azalide and a derivative of erythromycin. It belongs to the macrolide class of antibodies.

Application

Azithromycin has been used:

to treat synchronized Plasmodium falciparum Dd2 parasites for continuous growth assays to study the antiparasitic mechanisms of doxycycline (DOX)
to study its bactericidal activity against Pseudomonas aeruginosa in combination with a recombinant hemolymph plasma lectin (rHPLOE)
in evolution experiments to study P. aeruginosa strain PA14’s response to bacteriostatic antibiotics

Biochem/physiol Actions

Azithromycin is a broad-spectrum antimicrobial agent, effective against infections associated with respiratory tract, skin, tissues, and genital chlamydia. It acts against Gram-negative bacteria (including Enterobacteriaceae) and several Gram-positive organisms. It also acts against Plasmodium falciparum and P. vivax, which are multidrug resistance species that transmit malaria. Azithromycin targets the plasmodial ribosome and prevents protein synthesis. It is soluble in lipids and metabolizes in the liver by undergoing demethylation. It is commonly used to treat community-acquired pneumonia, sexually transmitted diseases, acute otitis media, and acute exacerbation of chronic obstructive pulmonary disease (COPD).

Features and Benefits

Rapidly absorbed
Shows great tissue penetration and procures high intracellular concentration
Distributes widely in body fluids and tissues

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS08,GHS09

signalword

Danger

hcodes

H317,H334,H410

pcodes

P261 - P272 - P273 - P280 - P284 - P302 + P352

Hazard Classifications

Aquatic Chronic 1 - Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

法规信息

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