A0384
魁蛤素 硫酸盐
别名:
1,4-双胍基丁烷 硫酸盐
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关于此项目
经验公式（希尔记法）:
C6H16N6 · H2O4S
化学文摘社编号:
分子量:
270.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
mp
>280 °C
solubility
1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
InChI
1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
InChI key
RWTGFMPOODRXIM-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
Application
Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
- to evaluate its effects on the acquisition of electrical kindling of the amygdala
- to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
- to study its effects on cell-free translation of synthetic polynucleotide
Biochem/physiol Actions
Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)