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文件

A7699

Sigma-Aldrich

腺苷 5'-三磷酸 二钠盐 水合物

BioXtra, ≥99% (HPLC), from microbial

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别名:
ATP 二钠盐
经验公式（希尔记法）:
C10H14N5Na2O13P3 · xH2O
CAS号:
34369-07-8
分子量:
551.14 (anhydrous basis)
EC 号:
213-579-1
MDL编号:
MFCD00150755
eCl@ss:
32160414
PubChem化学物质编号:
24891270
NACRES:
NA.51

生物来源

microbial

产品线

BioXtra

检测方案

≥99% (HPLC)

形式

powder

杂质

≤0.1% inorganic P
≤3% solvent content

pKa 

(1) 4.0, (2) 6.5

溶解性

H2O: 50 mg/mL, clear, colorless

痕量阴离子

chloride (Cl-): ≤0.05%

痕量阳离子

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.001%
Fe: ≤0.05%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

λmax

259 nm

储存温度

−20°C

SMILES字符串

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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应用

腺苷5γ-三磷酸腺苷(ATP)是体内能量储存和代谢的中心成分。 ATP应用于许多细胞过程、呼吸、生物合成反应、运动和细胞分裂。ATP是许多激酶的底物，这些激酶参与细胞信号和腺苷酸环化酶(s)，产生第二个信使 cAMP。 ATP提供代谢能量来驱动代谢泵。 ATP在一系列酶促反应中充当辅酶。

生化/生理作用

P2 嘌呤能激动剂；增加 Ca2+-激活的 K+ 通道的活性；ATP-依赖酶系统的底物

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)

分析证书(COA)

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T1503
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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the water content of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)? Does the formula weight listed on the website include water?

    The formula weight on the website does not include water as the amount of water in the product will vary from lot to lot. The water content for any specific lot will be reported on the Certificate of Analysis for that lot.

  4. What is the solubility of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)?

    ATP disodium salt is soluble in water (50 mg/mL), yielding a clear, colorless solution. This solution is mildly acidic (pH approximately 3.5).

  5. What is the stability of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP), in solution?

    Aqueous solutions of ATP are stable for months when frozen at -15°C and for approximately one week at 0°C. ADP is the first hydrolysis product formed, with additional hydrolysis leading to the formation of AMP. However, ATP solutions are only stable for several hours at 0 °C when dissolved in a trichloroacetic acid solution. In alkaline solution, it rapidly decomposes to inorganic pyrophosphate and adenosine 5'-phosphate even at 0 °C. This information can be found on the product information sheet (under Documents, above.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

N Liu et al.
Journal of animal science, 86(12), 3432-3439 (2008-08-19)
The effect of dietary phytate and phytase on carbohydrase activity and hexose transport was investigated in broiler chickens. Diets containing phytate P (2.2 or 4.4 g/kg) with different phytase dose rates (0, 500, or 1,000 phytase units/kg) were fed to
Mark W Gorman et al.
American journal of physiology. Heart and circulatory physiology, 299(6), H1981-H1989 (2010-09-21)
The adenine nucleotide hypothesis postulates that the ATP released from red blood cells is broken down to ADP and AMP in coronary capillaries and that ATP, ADP, and AMP act on purinergic receptors on the surface of capillary endothelial cells.
Stefan P Mortensen et al.
The Journal of physiology, 589(Pt 7), 1847-1857 (2011-02-09)
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Shaima'a Hamarsheh et al.
Nature communications, 11(1), 1659-1659 (2020-04-05)
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3
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实验方案

LC MS Analysis of Nucleotides Effect of pH

ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides SeQuant ZIC-cHILIC – Effect of pH

ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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