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B7651

布雷菲德菌素 A

from Penicillium brefeldianum, ≥99% (HPLC and TLC), powder, activator of the sphingomyelin cycle

别名:

Nectrolide, γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯, Ascotoxin, BFA, 布雷菲德菌素 A, 烟碱

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关于此项目

经验公式（希尔记法）:
C16H24O4
化学文摘社编号:
20350-15-6
分子量:
280.36
NACRES:
NA.77
PubChem Substance ID:
24278285
UNSPSC Code:
12352200
MDL number:
MFCD12913297
Beilstein/REAXYS Number:
25191
Assay:
≥99% (HPLC and TLC)
Form:
powder
Quality level:
300
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产品名称

布雷菲德菌素 A, from Penicillium brefeldianum, ≥99% (HPLC and TLC)

biological source

Penicillium brefeldianum

Quality Level

300

assay

≥99% (HPLC and TLC)

form

powder

solubility

DMSO: 10 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI key

KQNZDYYTLMIZCT-KQPMLPITSA-N

General description

布雷菲德菌素A（BFA）是一种13元大环内酯类真菌代谢产物。 可抑制蛋白与核酸合成。BFA可抑制腺苷核糖基化因子(ARF)上的GDP转化成GTP，从而阻止外被蛋白(β-COP)的结合，最终破坏高尔基体的结构和功能。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。布雷菲德菌素A可提高CRISPR介导的同源重组修复（HDR）效率。 具有多种生物活性，如抗肿瘤、抗病毒、抗生素、抗有丝分裂、抗真菌和抗线虫等。

Application

布雷菲德菌素A用于：



  • 提高CRISPR基因组编辑效率。
  • 细胞因子生产检测
  • 在细胞培养实验中抑制胞内运输

Biochem/physiol Actions

布雷菲德菌素A可提高CRISPR介导的同源重组修复（HDR）效率。
布雷菲德菌素A（BFA）是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。
破坏高尔基体的结构和功能；鞘磷脂循环的激活剂。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
088M4072V
059M4011V
14170517
14170308
037M4001V

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商品

CRISPR小分子增强剂

业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。

Small Molecule CRISPR Enhancers

Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

Marco Lepore et al.
Nature communications, 5, 3866-3866 (2014-05-17)
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the
Laura Jeanbart et al.
Cancer immunology research, 2(5), 436-447 (2014-05-06)
The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against tumor antigens are
Anniek B van der Waart et al.
Blood, 124(23), 3490-3500 (2014-10-23)
Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell-like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we investigated the in vivo existence of stem cell-like antigen-specific T cells
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全球贸易项目编号

货号GTIN
B7651-5MG04061838443816
B7651-25MG04061833442036