C1230
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone
≥90% (TLC), powder
别名:
Z-IETD-FMK
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关于此项目
经验公式（希尔记法）:
C30H43FN4O11
化学文摘社编号:
分子量:
654.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥90% (TLC)
form
powder
solubility
methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI
1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI key
CTXDBLYOEUERAT-VUVYEONESA-N
Application
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
- to study the activity of caspase-8 in porcine kidney cells
- to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
- to study its effects on retinal ganglion and astroglia in rat eyes
Biochem/physiol Actions
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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