C141
CGS-21680 盐酸盐 水合物
≥98% (HPLC), Adenosine A2A receptor agonist, solid
别名:
2-p-(2-羧乙基)苯乙氨基-5′-N-乙基甲酰胺基腺苷 盐酸盐 水合物
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关于此项目
经验公式（希尔记法）:
C23H29N7O6 · HCl · xH2O
化学文摘社编号:
分子量:
535.98 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CGS-21680 盐酸盐 水合物, solid
assay
≥98% (HPLC)
Quality Level
form
solid
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL
storage temp.
−20°C
SMILES string
O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23
InChI
1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1
InChI key
VIRPCGAECNOLOO-VBQNEDDFSA-N
Gene Information
human ... ADORA2A(135), ADORA2B(136)
Biochem/physiol Actions
腺苷受体激动剂，对 A 2 和 A 1 受体具有选择性。
Disclaimer
吸湿
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M F Jarvis et al.
The Journal of pharmacology and experimental therapeutics, 251(3), 888-893 (1989-12-01)
Characterization of the adenosine A2 receptor has been limited due to the lack of available ligands which have high affinity and selectivity for this adenosine receptor subtype. In the present study, the binding of a highly A2-selective agonist radioligand, [3H]CGS
J W Phillis
Brain research, 509(2), 328-330 (1990-02-19)
The A2 selective adenosine receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) depressed the spontaneous, acetylcholine- and glutamate-evoked firing of rat cerebral sensorimotor cortical neurons. Iontophoretically applied CGS 21680 was equipotent with adenosine as a depressant and its actions were antagonized by 8-p-sulphophenyltheophylline
N Levens et al.
The Journal of pharmacology and experimental therapeutics, 257(3), 1005-1012 (1991-06-01)
This study compares the renal actions of the A2 selective adenosine agonist, CGS 21680A, with the A1 selective adenosine agonist, N6-cyclopentyladenosine (CPA), and the nonselective agonist, 5'-N-ethylcarboxamide adenosine (NECA), in the anesthetized dog. Initial receptor binding studies in dog brain
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C141-10MG | 04061832081403 |
| C141-25MG | 04061832081410 |
| C141-100MG | 04061832089638 |
| C141-5MG | 04061833467510 |