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C8273

细胞松驰素D

From Zygosporium mansonii, ≥98% (TLC and HPLC), actin polymerization inhibitor, powder

别名:

细胞松弛素, 接柄孢菌素A

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关于此项目

经验公式（希尔记法）:
C30H37NO6
化学文摘社编号:
22144-77-0
分子量:
507.62
NACRES:
NA.77
PubChem Substance ID:
24893039
UNSPSC Code:
12352200
EC Number:
244-804-1
MDL number:
MFCD00077706
Beilstein/REAXYS Number:
1632828
Assay:
≥98% (TLC and HPLC)
Form:
powder
Quality level:
300
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产品名称

细胞松驰素D, from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

biological source

Zygosporium mansonii

Quality Level

300

assay

≥98% (TLC and HPLC)

form

powder

solubility

DMSO: soluble, ethanol: soluble

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChI key

SDZRWUKZFQQKKV-JHADDHBZSA-N

General description

细胞松弛素D（CytoD）常用于抑制肌动蛋白动力学，并用于研究其在细胞过程中的作用。通过结合G-肌动蛋白，这种来源于真菌的有机小分子化合物可作为G-肌动蛋白和丝切蛋白之间相互作用的抑制剂。此外，CytoD抑制丝切蛋白和F-肌动蛋白的结合，降低活细胞中肌动蛋白的聚合和解聚速率。
细胞松弛素D是一种细胞渗透性真菌毒素。它破坏肌动蛋白微丝并激活p53依赖性通路，引起细胞周期在G1-S过渡期阻滞。细胞松弛素D抑制平滑肌收缩和胰岛素刺激的、非基础的葡萄糖转运。

Application

细胞松弛素已用于:
  • 处理H9c2 细胞以研究细胞刚度和F-肌动蛋白细胞骨架的关系
  • 作为受体介导的内吞作用的抑制剂用于处理少突胶质前体细胞 (OPCs)，以研究其抑制特异性细胞外囊泡(EV) 摄取途径的作用
  • 在体外胚胎培养中用于人工激活卵母细胞

Biochem/physiol Actions

肌动蛋白聚合的强效抑制剂；可破坏肌动蛋白微丝；激活p53依赖性通路；抑制平滑肌收缩；抑制胰岛素刺激的葡萄糖转运。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
069M4071V
14181017
128M4013V
068M4013V
058M4035V

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商品

采用LentiBrite™ 慢病毒生物传感器进行细胞骨架蛋白的荧光活细胞成像

包含β-肌动蛋白、α-微管蛋白和波形蛋白用于细胞骨架结果蛋白活细胞分析的高滴度慢病毒颗粒。

Fluorescent Live Cell Imaging of Cytoskeleton Structure Proteins using LentiBrite™ Lentiviral Biosensors

High titer lentiviral particles including beta-actin, alpha-tubulin and vimentin used for live cell analysis of cytoskeleton structure proteins.

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全球贸易项目编号

货号GTIN
C8273-10MG04061833522042
C8273-1MG04061833522059
C8273-5MG04061833522066