D2390
达卡巴嗪
antineoplastic purine analog
别名:
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide, DTIC
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C6H10N6O
化学文摘社编号:
分子量:
182.18
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
224-396-1
MDL number:
Quality Level
form
powder or crystals
solubility
1 M HCl: 50 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI
1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key
FDKXTQMXEQVLRF-ZHACJKMWSA-N
Application
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
Biochem/physiol Actions
Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Still not finding the right product?
Explore all of our products under 达卡巴嗪
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges