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E1274

雌素酮

Name: 雌素酮
Brand: SIGMA

meets USP testing specifications

别名:

3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₂O₂

化学文摘社编号:

53-16-7

分子量:

270.37

EC Number:

200-164-5

UNSPSC Code:

12352200

PubChem Substance ID:

24894399

Beilstein/REAXYS Number:

1915077

MDL number:

MFCD00003620

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属性

agency

USP/NF, meets USP testing specifications

mp

258-260 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

说明

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

法规信息

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Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

Annamaria Lilienkampf et al.

Journal of medicinal chemistry, 52(21), 6660-6671 (2009-10-15)

Many breast tumors are hormone-dependent, and estrogens, especially estradiol (E2), have a pivotal role in their growth and development. 17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is a key enzyme in the biosynthesis of female sex steroids, catalyzing the NADPH-dependent reduction of

Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects.

Shanshan Zhao et al.

Breast cancer research : BCR, 16(2), R30-R30 (2014-03-29)

Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women's Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex

Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells.

Yoko Urata et al.

The Journal of clinical endocrinology and metabolism, 98(4), 1583-1590 (2013-03-02)

Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) expression in endometrioma stromal cells (ESCs) and increases the

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