M1547
甲硝唑
BioXtra
别名:
2-甲基-5-硝基咪唑-1-乙醇
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关于此项目
经验公式（希尔记法）:
C6H9N3O3
化学文摘社编号:
分子量:
171.15
UNSPSC Code:
51282808
NACRES:
NA.76
PubChem Substance ID:
EC Number:
207-136-1
Beilstein/REAXYS Number:
611683
MDL number:
product line
BioXtra
impurities
≤0.2% Total Impurities
ign. residue
≤0.1%
color
white to light yellow
mp
159-161 °C (lit.)
solubility
acetic acid: 0.1 M, clear, colorless to yellow
anion traces
chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.01%, Pb: ≤0.001%, Zn: ≤0.0005%
antibiotic activity spectrum
Gram-negative bacteria, parasites
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CC1=NC=C([N+]([O-])=O)N1CCO
InChI
1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChI key
VAOCPAMSLUNLGC-UHFFFAOYSA-N
General description
化学结构：咪唑
Application
甲硝唑用于研究DNA损伤和修复，并可诱导猪痢疾密螺旋体（Brachyspira hyodysenteriae）中的基因转移因子VSH-1。 它通常用于治疗牙周炎，并用于生物利用度研究。
Biochem/physiol Actions
甲硝哒唑是一种前药，对厌氧菌具有选择性，因为它们能够在细胞内将甲硝哒唑还原为活性形式。还原甲硝唑与脱氧核糖核酸共价结合，破坏其螺旋结构，诱导脱氧核糖核酸链断裂并抑制细菌核酸合成。最终导致细菌细胞死亡。
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signalword
Danger
hcodes
Hazard Classifications
Carc. 1B - Muta. 1B - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves