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Merck
CN

N1876

新霉素 三硫酸盐 水合物

powder

别名:

Framycetin sulfate

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关于此项目

经验公式(希尔记法):
C23H46N6O13 · 3H2SO4 · xH2O
化学文摘社编号:
分子量:
908.88 (anhydrous basis)
PubChem Substance ID:
UNSPSC Code:
51101500
NACRES:
NA.85
EC Number:
215-773-1
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form

powder

Quality Level

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

SMILES string

O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O

InChI

1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1

InChI key

WHAGUNPVKDUVFV-QGTTWHFQSA-N

General description

Chemical structure: aminoglycoside

Application

Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo), and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins..

Biochem/physiol Actions

作用方式:该产品通过和30S以及50S亚基结合,引起错编,抑制蛋白质合成过程的起始和延长。 新霉素也可阻断电压敏感的Ca2+ 通道,而不会影响神经元中Na+/Ca2+逆向转运蛋白。

抗菌谱:新霉素能够作用于革兰氏阳性和阴性细菌。

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place


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signalword

Danger

hcodes

pictograms

Health hazard

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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